Latest Projects

ReVAMP – Reverse vaccinology approach for the prevention of mycobacterial disease in cattle

Reverse Vaccinology Approach for the Prevention of Mycobacterial Diseases in Cattle (ReVAMP)
Infections are a leading cause of sickness and death in cattle, causing direct economic losses to producers and even more serious losses associated with international trade restrictions (as seen with mad cow disease) and decreased public confidence in food quality.

The most effective way to prevent infectious disease in animals such as cattle is vaccination. Lack of effective vaccines for some diseases contributes to the overuse of antibiotics and the strategy of slaughtering infected animals, which has come under increasing public scrutiny.

Bovine Tuberculosis (bTB) is a debilitating disease of cattle that can spread to humans and other domestic and wild animals and Johne’s disease (JD) is a contagious and chronic disease of cattle. These are common diseases of high economic importance to the Agri-food industry in Canada however, there is no effective vaccine to protect cattle against these diseases.

The overarching goal of the ReVAMP project which was led by Drs. Volker Gerdts and Andrew Potter of VIDO-InterVac, University of Saskatchewan, and Robert Hancock of the University of British Columbia, was to use genomics and reverse vaccinology to develop vaccines for two cattle diseases, Johne’s disease and Bovine tuberculosis.

The ReVAMP project used genomic technology to screen large numbers of bacterial proteins to identify those that have properties that can stimulate a protective immune response in cattle. The identified proteins then formed the basis for developing novel vaccines and immunization strategies.

Highlights of project outcomes include (i) a number of key white papers with novel information for the public, producers, industry and government on the options and strategies for dealing with these important cattle diseases, (ii) identification and testing of candidate proteins that could be used as vaccines against these two diseases, (iii) the development of new infection and vaccine screening models for JD and bTB, and (iv) the creation of a framework to facilitate core research programs for these important national & global diseases.

Overall, the findings from this project provide a platform for Canadian researchers to lead national & global collaborations into vaccines & therapeutics research for Bovine Tuberculosis and Johne’s disease.

Quick Facts

  • Project Leader(s):
    • Volker Gerdts
      (VIDO-InterVac, University of Saskatchewan)
    • Andrew Potter (Retired)
      (VIDO-InterVac, University of Saskatchewan)
    • Robert Hancock
      (University of British Columbia)
  • Co-Lead Centres:
    • Genome Prairie
      (University of Saskatchewan)
    • Susan Farmer
      (University of British Columbia)
  • Project Manager:

    Elodie Pastural University of Saskatchewan

    Susan Farmer University of British Columbia

  • Project Value:

    $7.4 Million

  • Funding Partners Contribution:

    VIDO-InterVac
    Genome British Columbia
    Total: $4.4 Million

  • Genome Canada Contribution:

    $2.9 Million

  • Project Status:

    (2015-2021)

  • Competition:

    Genome Canada 2014 Large Scale Applied Research Project Competition

Current Projects

2022 - Present

Bison Integrated Genomics (BIG)

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2016-2022

CanCOGeN – Canadian COVID-19 Genomics Network

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2021-2024

CPMN – Canadian Prairie Metabolic Network

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2020 - 2022

COV3R – COVID-19 Rapid Regional Response

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2015-2021

CTAG2 – Canadian Triticum Applied Genomics

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2019 to 2023

4DWheat – Diversity, Discovery, Design and Delivery

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2016-2021

EcoToxChip – A toxicogenomics tool for chemical prioritization and environmental management

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2019 - 2023

EVOLVES – Enhancing the Value of Lentil Variation for Ecosystem Survival

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2019 - 2022

FLOWTER – Floating Wetland Treatments to Enhance Remediation

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2016-2022

GENICE II

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2019 - 2023

Genomic ASSETS (Antimicrobial Stewardship Systems from Evidence-based Treatment Strategies) for Livestock

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2016-2022

GENICE: Microbial Genomics for Oil Spill Preparedness in Canada’s Arctic Marine Environment

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2018 - 2021

Improving on-seed survival and performance of legume inoculants using genome shuffling

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