Latest Projects

CPMN – Canadian Prairie Metabolic Network

nborn errors of metabolism (IEM) are genetic diseases caused by mutations in either the nuclear or mitochondrial genome. Although each of the more than 600 known IEMs is individually rare, together they affect more than 6,400 patients in the Prairies—primarily children. Throughout the Prairie provinces, there is a limited local capacity for next-generation sequencing causing delays which limit the benefits of early diagnosis, early treatment, and improved outcomes. These delays result in adverse outcomes in patients. This project will combine clinical and laboratory approaches to ensure patients have timely access to new diagnostics, new therapies, and clinical and specialty supports.

The Canadian Prairie Metabolic Network (CPMN) will provide access to a full range of multidisciplinary expertise, develop best practice approaches, and provide, as needed, clinical specialist coverage for generalist physicians and their patients. It will also ensure the timely and more cost-effective delivery of innovative and relevant genomic testing in the Prairies, including rapid, inexpensive mitochondrial DNA testing not available elsewhere; generate genomics data that will stay in Canada; and contribute to knowledge and expertise in Canada across multiple disciplines and specialties. The result will be the timely treatment and improved outcomes for IEM patients.

Part of Genome Canada’s All for One initiative. This clinical implementation project will facilitate the uptake of genome-wide sequencing as a standard of care for rare diseases by the relevant ministries of health. It is funded as part of the All for One initiative, the goal of which is to improve the health and wellness of Canadians with serious genetic conditions by enabling access to a timely and accurate genomic-based diagnosis. Moreover, All for One will enable patients to benefit while helping others through the sharing of their clinical and genomic data within a learning health system. It lays a foundation for precision health in Canada.

Quick Facts

  • Project Leader(s):
    • Cheryl Rockman-Greenberg
      (University of Manitoba)
  • Genome Centre(s):

    Genome Prairie, Genome Alberta

  • Project Value:

    $6.1 million

  • Genome Canada Contribution:

    $1,996,716

  • Receptor Leader(s):

    Petr Kresta, Shared Health Manitoba

  • Other Funding Partners:

    Shared Health Manitoba, Discovery DNA

  • Project Status:

    Ongoing (2021-2024)

  • Competition:

    Genomic Applications Partnership Program

Current Projects

2022 - Present

Bison Integrated Genomics (BIG)

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2016-2022

CanCOGeN – Canadian COVID-19 Genomics Network

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2021-2024

CPMN – Canadian Prairie Metabolic Network

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2020 - 2022

COV3R – COVID-19 Rapid Regional Response

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2015-2021

CTAG2 – Canadian Triticum Applied Genomics

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2019 to 2023

4DWheat – Diversity, Discovery, Design and Delivery

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2016-2021

EcoToxChip – A toxicogenomics tool for chemical prioritization and environmental management

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2019 - 2023

EVOLVES – Enhancing the Value of Lentil Variation for Ecosystem Survival

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2019 - 2022

FLOWTER – Floating Wetland Treatments to Enhance Remediation

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2016-2022

GENICE II

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2019 - 2023

Genomic ASSETS (Antimicrobial Stewardship Systems from Evidence-based Treatment Strategies) for Livestock

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2016-2022

GENICE: Microbial Genomics for Oil Spill Preparedness in Canada’s Arctic Marine Environment

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2018 - 2021

Improving on-seed survival and performance of legume inoculants using genome shuffling

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